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1

Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase

Ohkanda, Junko, Strickland, Corey L., Blaskovich, Michelle A., Carrico, Dora, Lockman, Jeffrey W., Vogt, Andreas, Bucher, Cynthia J., Sun, Jiazhi, Qian, Yimin, Knowles, David, Pusateri, Erin E., Sebti

Journal:

Organic & Biomolecular Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 322 KB

english, 2006

2

Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase

Hayashi, Daisuke, Kato, Nobuo, Kuzuyama, Tomohisa, Sato, Yasuo, Ohkanda, Junko

Journal:

Chemical Communications

Année:

2013

Langue:

english

Fichier:

PDF, 1.98 MB

english, 2013

3

A Novel Fusicoccin Derivative Preferentially Targets Hypoxic Tumor Cells and Inhibits Tumor Growth in Xenografts

Kawakami, Koshi, Hattori, Miho, Inoue, Takatsugu, Maruyama, Yuriko, Ohkanda, Junko, Kato, Nobuo, Tongu, Miki, Yamada, Takaya, Akimoto, Miho, Takenaga, Keizo, Sassa, Takeshi, Suzumiy, Junji, Honma, Yos

Journal:

Anti-Cancer Agents in Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 795 KB

english, 2012

4

Phosphopeptide-Dependent Labeling of 14–3–3 ζ Proteins by Fusicoccin-Based Fluorescent Probes

Michiko Takahashi, Akie Kawamura, Prof. Nobuo Kato, Prof. Tsuyoshi Nishi, Prof. Itaru Hamachi, Prof. Junko Ohkanda

Journal:

Angewandte Chemie

Année:

2012

Langue:

english

Fichier:

PDF, 894 KB

english, 2012

5

Phosphopeptide-Dependent Labeling of 14–3–3 ζ Proteins by Fusicoccin-Based Fluorescent Probes

Michiko Takahashi, Akie Kawamura, Prof. Nobuo Kato, Prof. Tsuyoshi Nishi, Prof. Itaru Hamachi, Prof. Junko Ohkanda

Journal:

Angewandte Chemie International Edition

Année:

2012

Langue:

english

Fichier:

PDF, 902 KB

english, 2012

6

Module Assembly for Protein-Surface Recognition: Geranylgeranyltransferase I Bivalent Inhibitors for Simultaneous Targeting of Interior and Exterior Protein Surfaces

Shinnosuke Machida, Kakeru Usuba, Michelle A. Blaskovich, Akiko Yano, Kazuo Harada, Saïd M. Sebti, Nobuo Kato, Junko Ohkanda

Journal:

Chemistry - A European Journal

Année:

2008

Langue:

english

Fichier:

PDF, 992 KB

english, 2008

7

ChemInform Abstract: N-Hydroxyamide-containing Heterocycles: Synthesis, Reactivities, and Fe(III)-Chelating Properties

Junko Ohkanda, Akira Katoh

Journal:

Année:

1999

Fichier:

PDF, 25 KB

1999

8

ChemInform Abstract: Synthesis of 2,2′-Bipyridines Bearing Amino or Carboxyl Group at the Side Chain and Physical Properties of Their Ruthenium(II) Complexes.

Akira Katoh, Yoshihiro Kitamura, Hideyuki Fujii, Yumi Horie, Tetsuji Satoh, Junko Ohkanda, Yoshinobu Yokomori

Journal:

Année:

1999

Fichier:

PDF, 33 KB

1999

9

ChemInform Abstract: Synthesis of Quinoxaline Derivatives Bearing the Styryl and Phenylethynyl Groups and Application to a Fluorescence Derivatization Reagent.

Akira Katoh, Tohru Yoshida, Junko Ohkanda

Journal:

Année:

2000

Fichier:

PDF, 35 KB

2000

10

In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability

Dora Carrico, Junko Ohkanda, Howard Kendrick, Kohei Yokoyama, Michelle A. Blaskovich, Cynthia J. Bucher, Frederick S. Buckner, Wesley C. Van Voorhis, Debopam Chakrabarti, Simon L. Croft, Michael H. Ge

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 411 KB

english, 2004

11

Unusual substituent effect by the α-acetyl group on the type II photoreaction of valerophenones: strong wavelength dependence of quantum yields

Tadashi Hasegawa, Junko Ohkanda, Mariko Kobayashi, Michikazu Yoshioka

Journal:

Journal of Photochemistry and Photobiology A: Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 583 KB

english, 1992

12

Development of a Tripeptide Mimetic Strategy for the Inhibition of Protein Farnesyltransferase

Mohit A. Kotharé, Junko Ohkanda, Jeffrey W. Lockman, Yimin Qian, Michelle A. Blaskovich, Said M. Sebti, Andrew D. Hamilton

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 174 KB

english, 2000

13

Synthesis of homocalix[3]arene bearing hydroxypyrazinone and its cooperative molecular recognition by metal-mediated allosteric effect

Junko Ohkanda, Hiroyuki Shibui, Akira Katoh

Journal:

Journal of Inorganic Biochemistry

Année:

1997

Langue:

english

Fichier:

PDF, 86 KB

english, 1997

14

Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity

Junko Ohkanda, Jeffrey W. Lockman, Kohei Yokoyama, Michael H. Gelb, Simon L. Croft, Howard Kendrick, Maria Isabel Harrell, Jean E. Feagin, Michelle A. Blaskovich, Said M. Sebti, Andrew D. Hamilton

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 129 KB

english, 2001

15

N-Hydroxyamide-Containing Heterocycles. Part 5.1 Synthesis of Novel Hexadentate Ligands Composed of N-Hydroxy-2(1H)-pyrazinone, Aliphatic Diamine, and 1,1,1-Tris(carboxyethoxymethyl)ethane, and Properties of Their Ferric Complexes

Junko Ohkanda, Akira Katoh

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 589 KB

english, 1995

16

Inhibition of farnesyltransferase increases TGFβ type II receptor expression and enhances the responsiveness of human cancer cells to TGFβ

Adnane, Jalila, Bizouarn, Francisco A, Chen, Zhi, Ohkanda, Junko, Hamilton, Andrew D, Munoz-Antonia, Teresita, Sebti, Saïd M

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 308 KB

english, 2000

17

Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for α-chymotrypsin and cytochrome c

Yoshinobu Yamaguchi, Nobuo Kato, Hideki Azuma, Takeshi Nagasaki, Junko Ohkanda

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 718 KB

english, 2012

18

Structural aspects of the mechanical and thermal dissociation of the central bond in 2,2?-bis(2,3,4-triarylchromenyl)s

Ohkanda, Junko, Mori, Yukie, Maeda, Koko, Osawa, Eiji

Journal:

Journal of the Chemical Society Perkin Transactions 2

Année:

1992

Langue:

english

Fichier:

PDF, 511 KB

english, 1992

19

Requirement for Geranylgeranyl Transferase I and Acyl Transferase in the TGF-β-Stimulated Pathway Leading to Elastin mRNA Stabilization

Umberto Kucich, Joan C Rosenbloom, Gloria Shen, William R Abrams, Michelle A Blaskovich, Andrew D Hamilton, Junko Ohkanda, Saı̈d M Sebti, Joel Rosenbloom

Journal:

Biochemical and Biophysical Research Communications

Année:

1998

Langue:

english

Fichier:

PDF, 265 KB

english, 1998

20

Synthesis of Quinoxaline Derivatives Bearing the Styryl and Phenylethynyl Groups and Application to a Fluorescence Derivatization Reagent

Katoh, Akira, Yoshida, Tohru, Ohkanda, Junko

Journal:

Année:

2000

Fichier:

PDF, 524 KB

2000

21

Design and Synthesis of Potent Nonpeptidic Farnesyltransferase Inhibitors Based on a Terphenyl Scaffold

Ohkanda, Junko, Lockman, Jeffrey W., Kothare, Mohit A., Qian, Yimin, Blaskovich, Michelle A., Sebti, Said M., Hamilton, Andrew D.

Journal:

Journal of Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 220 KB

english, 2002

22

Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors

Machida, Shinnosuke, Tsubamoto, Mai, Kato, Nobuo, Harada, Kazuo, Ohkanda, Junko

Journal:

Bioorganic & Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 948 KB

english, 2013

23

Novel Iron Sequestering Agents: Synthesis and Iron-Chelating Properties of Hexadentate Ligands Composed of 1-Hydroxy-2(1 H )-pyrimidinone, ω-Amino Carboxylic Acid, and Tris(2-aminoethyl)amine

Ohkanda, Junko, Kamitani, Jun, Tokumitsu, Takeshi, Hida, Yoko, Konakahara, Takeo, Katoh, Akira

Journal:

Journal of Organic Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 232 KB

english, 1997

24

Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers

Molzan, Manuela, Kasper, Stefan, Röglin, Lars, Skwarczynska, Malgorzata, Sassa, Takeshi, Inoue, Takatsugu, Breitenbuecher, Frank, Ohkanda, Junko, Kato, Nobuo, Schuler, Martin, Ottmann, Christian

Journal:

ACS Chemical Biology

Année:

2013

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2013

25

Structurally Simple Inhibitors of Lanosterol 14α-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease

Suryadevara, Praveen Kumar, Olepu, Srinivas, Lockman, Jeffrey W., Ohkanda, Junko, Karimi, Mandana, Verlinde, Christophe L. M. J., Kraus, James M., Schoepe, Jan, Van Voorhis, Wesley C., Hamilton, Andre

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 301 KB

english, 2009

26

Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti- Trypanosoma brucei Agents

Ohkanda, Junko, Buckner, Frederick S., Lockman, Jeffrey W., Yokoyama, Kohei, Carrico, Dora, Eastman, Richard, de Luca-Fradley, Kate, Davies, Wendy, Croft, Simon L., Van Voorhis, Wesley C., Gelb, Micha

Journal:

Journal of Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 237 KB

english, 2004

27

RNA-Directed Amino Acid Coupling as a Model Reaction for Primitive Coded Translation

Harada, Kazuo, Aoyama, Shoko, Matsugami, Akimasa, Kumar, Penmetcha K. R., Katahira, Masato, Kato, Nobuo, Ohkanda, Junko

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 636 KB

english, 2014

28

New hexadentate ligands composed of 1-hydroxy-2(1H )-pyrimidinone, α,ω-diamine and 1,1,1-tris(carboxyethoxymethyl)ethane or tri(carboxybutyl)isocyanurate. Synthesis and characterization of their iron(III) complexes

Katoh, Akira, Hida, Yoko, Kamitani, Jun, Ohkanda, Junko

Journal:

Journal of the Chemical Society Dalton Transactions

Année:

1998

Langue:

english

Fichier:

PDF, 212 KB

english, 1998

29

Transannular Proton Transfer in the Cyclization of Geranylgeranyl Diphosphate to Fusicoccadiene, a Biosynthetic Intermediate of Fusicoccins

Toyomasu, Tomonobu, Tsukahara, Mai, Kenmoku, Hiromichi, Anada, Masahide, Nitta, Hajime, Ohkanda, Junko, Mitsuhashi, Wataru, Sassa, Takeshi, Kato, Nobuo

Journal:

Organic Letters

Année:

2009

Langue:

english

Fichier:

PDF, 1.95 MB

english, 2009

30

Potent, Highly Selective, and Non-Thiol Inhibitors of Protein Geranylgeranyltransferase-I

Vasudevan, Anil, Qian, Yimin, Vogt, Andreas, Blaskovich, Michelle A., Ohkanda, Junko, Sebti, Said M., Hamilton, Andrew D.

Journal:

Journal of Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 197 KB

english, 1999

31

Bivalent Inhibitors for Disrupting Protein Surface-Substrate Interactions and for Dual Inhibition of Protein Prenyltransferases

Machida, Shinnosuke, Kato, Nobuo, Harada, Kazuo, Ohkanda, Junko

Journal:

Journal of the American Chemical Society

Année:

2011

Langue:

english

Fichier:

PDF, 2.29 MB

english, 2011

32

N-Hydroxyamide-Containing Heterocycles. Part 4. Synthesis and FeIII-Chelating Properties of Novel Hexadentate Ligands Composed of N-Hydroxy-2(1H)-Pyrazinone, Amino Acid Residues, and Tris(2-aminoethyl)amine

Ohkanda, Junko, Katoh, Akira

Journal:

Journal of Organic Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 826 KB

english, 1995

33

N-Hydroxypyrazinone-bearing homotrioxacalix[3]arene: its cooperative molecular recognition by metal complexation

Ohkanda, Junko, Shibui, Hiroyuki

Journal:

Chemical Communications

Année:

1998

Langue:

english

Fichier:

PDF, 69 KB

english, 1998

34

Protein surface recognition by dendritic ruthenium(ii) tris(bipyridine) complexes

Ohkanda, Junko, Satoh, Ritsuko, Kato, Nobuo

Journal:

Chemical Communications

Année:

2009

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2009

35

Module Assembly for Designing Multivalent Mid-Sized Inhibitors of Protein-Protein Interactions

Journal:

The Chemical Record

Année:

2013

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2013

36

Cover Picture: RNA-Directed Amino Acid Coupling as a Model Reaction for Primitive Coded Translation (ChemBioChem 6/2014)

Harada, Kazuo, Aoyama, Shoko, Matsugami, Akimasa, Kumar, Penmetcha K. R., Katahira, Masato, Kato, Nobuo, Ohkanda, Junko

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 440 KB

english, 2014

37

A Convenient Synthesis of 3-(Aryl)substituted 2,4(1H,3H)-Pteridinediones and Their Absorption and Fluorescence Spectorscopic Characteristics

Katoh, Akira, Ohkanda, Junko, Sato, Hiroshi, Sakamoto, Tsuyoshi, Mitsuhashi, Keiryo

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 142 KB

english, 1993

38

N-HYDROXYAMIDE-CONTAINING HETEROCYCLES. PART 6. APPLICATION OF 1-HYDROXY- 4,6-DIMETHYL-2(1H)-PYRIMIDINONE TO A NEW BENZYLOXYCARBONYLATING AGENT

Katoh, Akira, Kondoh, Syoichi, Ohkanda, Junko

Journal:

Heterocyclic Communications

Année:

1996

Langue:

english

Fichier:

PDF, 646 KB

english, 1996

39

Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions

Parvatkar, Prakash, Kato, Nobuo, Uesugi, Motonari, Sato, Shin-ichi, Ohkanda, Junko

Journal:

Journal of the American Chemical Society

Année:

2015

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2015

40

Synthesis of 2,2'-Bipyridines Bearing Amino or Carboxyl Group at the Side Chain and Physical Properties of Their Ruthenium(II) Complexes

Katoh, Akira, Kitamura, Yoshihiro, Fujii, Hideyuki, Horie, Yumi, Satoh, Tetsuji, Ohkanda, Junko, Yokomori, Yoshinobu

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 480 KB

english, 1998

41

Synthesis of 2,3-Disubstituted 6-Aminoquinoxalines and Their Application to New Fluorescence Derivatization Reagents for Carboxylic Acids

Katoh, Akira, Takahashi, Motoki, Ohkanda, Junko

Journal:

Chemistry Letters

Année:

1996

Fichier:

PDF, 348 KB

1996

42

The Influence of the Chirality of Synthetic Iron Chelators Bearing N -Hydroxy-2(1 H )-pyrazinones and Amino Acid Residues upon Iron Removal from Human Transferrin

Ohkanda, Junko, Katoh, Akira

Journal:

Chemistry Letters

Année:

1996

Fichier:

PDF, 273 KB

1996

43

N-Hydroxyamide-containing Heterocycles. New Effective Additives for Peptide Synthesis by the Dicyclohexylcarbodiimide Method

Katoh, Akira, Ohkanda, Junko, Itoh, Yoshifumi, Mitsuhashi, Keiryo

Journal:

Chemistry Letters

Année:

1992

Fichier:

PDF, 345 KB

1992

44

N -Hydroxyamide-Containing Heterocycles. Part 2. Synthesis and Iron(III) Complex-Forming Tendency of 1-Hydroxy-2(1 H )-pyrimidinone and -pyrazinone

Ohkanda, Junko, Tokumitsu, Takeshi, Mitsuhashi, Keiryo, Katoh, Akira

Journal:

Bulletin of the Chemical Society of Japan

Année:

1993

Fichier:

PDF, 1.05 MB

1993

45

Synthesis of 2(1H)-Pyrimidinone-Containing .ALPHA.-Amino Acid Derivatives by Chemical Modification of L-Glutamic Acid.

KATOH, Akira, INOKAWA, Mika, OHKANDA, Junko, MITSUHASHI, Keiryo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Année:

1994

Fichier:

PDF, 587 KB

1994

46

Protein-guided Self-Assembly for Controlling Protein–Protein Interactions

Journal:

Journal of The Society of Japanese Women Scientists

Année:

2017

Langue:

english

Fichier:

PDF, 4.92 MB

english, 2017

47

3-Hydroxy-4(1H)-pyridinone-containing Linear and Cyclic Hexapeptides and Their Iron(III) Complexes —Synthesis, Property, and the Growth-Promotion Activity —

Katoh, Akira, Hikita, Yasushi, Harata, Manabu, Ohkanda, Junko, Tsubomura, Taro, Higuchi, Akon, Saito, Ryota, Harada, Kazuo

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 490 KB

english, 2001

48

Structural Effect of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity

Ohkanda, Junko, Kusumoto, Atsushi, Punzalan, Louvy, Masuda, Ryoma, Wang, Chenyu, Parvatkar, Prakash, Akase, Dai, Aida, Misako, Uesugi, Motonari, Higuchi, Yusuke, Kato, Nobuo

Journal:

Chemistry - A European Journal

Année:

2018

Langue:

english

Fichier:

PDF, 2.03 MB

english, 2018

49

Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity

Ohkanda, Junko, Kusumoto, Atsushi, Punzalan, Louvy, Masuda, Ryoma, Wang, Chenyu, Parvatkar, Prakash, Akase, Dai, Aida, Misako, Uesugi, Motonari, Higuchi, Yusuke, Kato, Nobuo

Journal:

Chemistry - A European Journal

Année:

2018

Fichier:

PDF, 5.17 MB

2018

50

Inhibitors of Protein Farnesyltransferase as Novel Anticancer Agents

Ohkanda, Junko, Knowles, David, Blaskovich, Michelle, Sebti, Said, Hamilton, Andrew

Journal:

Current Topics in Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 149 KB

english, 2002